Bioactive material‑sodium alginate-polyvinyl alcohol composite film scaffold for bone tissue engineering application
Shital S Shendage1, Kranti Kachare1, Kajal Gaikwad2
1Green Nanotechnology Laboratory, Department of Chemistry, Shivaji University, Kolhapur 416004, India.
International Journal of Biological Macromolecules
|July 15, 2024
Summary
This study developed a sustainable bioactive composite film for bone tissue engineering. The material demonstrated excellent biocompatibility, accelerated bone healing, and promoted new blood vessel growth, offering a promising orthopedic solution.
Area of Science:
- Biomaterials Science
- Orthopedic Engineering
- Regenerative Medicine
Background:
- Road accidents and surgical infections pose significant challenges in orthopedics.
- Developing advanced materials for bone tissue engineering is crucial for improving patient outcomes.
Purpose of the Study:
- To synthesize and characterize a novel bioactive composite film for bone tissue engineering.
- To evaluate the biocompatibility, bioactivity, and osteogenic potential of the developed material.
Main Methods:
- Sustainable synthesis of 70S30C calcium silicate bioactive material (BM) using recycled rice husk and eggshells.
- Composite film preparation using sodium alginate (SA) and polyvinyl alcohol (PVA) via solvent casting.
- Comprehensive characterization including BET, XRD, ATR-FTIR, SEM, EDS, in vitro bioactivity, biodegradation, hemocompatibility, and CAM assays, alongside in vivo biocompatibility and osteogenesis studies.
Main Results:
- The 70S30C BM composite films exhibited excellent in vitro bioactivity and biodegradation.
- The material demonstrated hemocompatibility, good neovascularization (angiogenesis), and non-toxicity through in vitro and in vivo assays.
- In vivo studies confirmed accelerated osteogenesis, indicating enhanced bone regeneration.
Conclusions:
- The developed sustainable bioactive composite film shows significant potential for bone tissue engineering applications.
- The material's properties including bioactivity, hemocompatibility, angiogenesis, and osteogenesis make it a promising candidate for orthopedic treatments.
