Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dose-intensity analysis for CHOP chemotherapy in diffuse aggressive large cell lymphoma.

R Epelbaum1, N Haim, M Ben-Shahar

  • 1Department of Oncology, Rambam Medical Center, Haifa, Israel.

Israel Journal of Medical Sciences
|September 1, 1988
PubMed
Summary

High dose intensity of chemotherapy, particularly cyclophosphamide, is linked to better outcomes in diffuse large cell lymphoma. Achieving complete remission and improved survival rates were associated with higher relative dose intensity (RDI).

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sacral neuromodulation for the treatment of faecal incontinence following proctectomy.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2016
Same author

Regional lymph node status after neoadjuvant chemoradiation of rectal cancer producing a complete or near complete rectal wall response.

Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland·2015
Same author

Overall survival and clinical characteristics of pancreatic cancer in BRCA mutation carriers.

British journal of cancer·2014
Same author

Heparanase procoagulant activity is elevated and predicts survival in non-small cell lung cancer patients.

Thrombosis research·2014
Same author

The 2014 Jagelman/Turnbull International Colorectal Disease Symposium, Ft Lauderdale (FL).

Techniques in coloproctology·2014
Same author

Soluble endothelial protein C receptor and coagulation parameters as prognostic factors in non-small cell lung carcinoma.

Journal of thrombosis and haemostasis : JTH·2013

Area of Science:

  • Oncology
  • Pharmacology

Background:

  • Dose intensity is a critical factor in cancer chemotherapy efficacy.
  • Non-Hodgkin's lymphoma (NHL) treatment outcomes can be influenced by chemotherapy regimens.

Purpose of the Study:

  • To investigate the relationship between relative dose intensity (RDI) of the cyclophosphamide, adriamycin, vincristine, and prednisone (CHOP) regimen and therapeutic outcomes.
  • To determine if higher RDI correlates with improved complete remission (CR) rates and survival in patients with diffuse large cell lymphoma.

Main Methods:

  • Retrospective analysis of 78 newly diagnosed diffuse histiocytic and mixed non-Hodgkin's lymphoma patients.
  • Calculation of RDI for the CHOP regimen, cyclophosphamide (CTX), and adriamycin.
  • Comparison of RDI between complete responders and non-complete responders.

Related Experiment Videos

  • Correlation of CTX RDI with 5-year actuarial survival.

    • Main Results:

    • Complete remission (CR) achievement was significantly associated with higher average RDI, CTX RDI, and adriamycin RDI (P < 0.05).
    • Patients achieving CR were more likely to have an average RDI > 0.8 (52% vs. 23%).
    • Higher CTX RDI (> 0.7) significantly correlated with improved 5-year survival (81% vs. 54%, P < 0.05).

    Conclusions:

    • A clear dose-rate effect of the CHOP regimen, especially cyclophosphamide, on therapeutic outcomes was observed.
    • High relative dose intensity (RDI) is crucial for improving treatment results in diffuse large cell lymphoma.
    • Maintaining high dose intensity, particularly for cyclophosphamide, may enhance survival in these patients.