Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Energy Basics02:27

Energy Basics

47.6K
Chemical reactions, such as those that occur when you light a match, involve changes in energy as well as matter.
47.6K
Basicity of Aliphatic Amines01:21

Basicity of Aliphatic Amines

6.9K
Amines can behave as Brønsted–Lowry bases by accepting a proton from the acid to form corresponding conjugate acids. Due to a lone pair of nonbonding electrons, aliphatic amines can also act as Lewis bases by forming a covalent bond with an electrophile.
To measure the basicity of amines, two conventions are generally used. The first defines Kb as the basicity constant for the deprotonation reaction of water by the amine, as presented in Figure 1. Conventionally, lower Kb indicates higher...
6.9K
Basic Operations on Signals01:22

Basic Operations on Signals

1.1K
Basic signal operations include time reversal, time scaling, time shifting, and amplitude transformations. These operations are fundamental in signal processing and analysis.
Time Reversal mirrors a continuous-time signal about the vertical axis at t=0. This is achieved by substituting t with −t. For example, if a signal x(t) is considered, the time-reversed signal is x(−t). This operation can be graphically represented, showing the mirrored signal.
1.1K
VSEPR Theory and the Basic Shapes02:52

VSEPR Theory and the Basic Shapes

84.6K
Overview of VSEPR Theory
84.6K
Basic Concept01:28

Basic Concept

6.2K
Engineering mechanics is a branch of engineering that studies motion and the forces acting on objects. It is a fundamental subject and forms the basis of many other engineering disciplines. Length, time, mass, and force are some basic concepts in engineering mechanics.
Length, which measures the distance traveled by an object, is a fundamental concept in engineering mechanics. We use coordinates relative to a reference point to describe the distance. Length not only helps to describe the...
6.2K
Acidity and Basicity of Alcohols and Phenols02:36

Acidity and Basicity of Alcohols and Phenols

22.1K
Like water, alcohols are weak acids and bases. This is attributed to the polarization of the O–H bond making the hydrogen partially positive. Moreover, the electron pairs on the oxygen atom of alcohol make it both basic and nucleophilic. Protonation of an alcohol converts hydroxide, a poor leaving group, into water—a good one. The two acid–base equilibria corresponding to ethanol are depicted below.
22.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Early Persistent Kidney Injury and Long-Term Outcomes Following Lung Transplantation.

Clinical transplantation·2026
Same author

Bacteriophages as Immune Modulators: Current Insights and Future Directions.

PHAGE (New Rochelle, N.Y.)·2026
Same author

Less severe alcoholic injury in cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) deficient mice, a possible impact of intracellular DNA recognition.

International immunopharmacology·2026
Same author

Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: Implications for sepsis susceptibility in immunocompromised hosts.

Animal models and experimental medicine·2026
Same author

Critical care access and outcomes in residents of inpatient-care catchment areas with and without ICUs: a nationwide cohort study in Japan.

The Lancet regional health. Western Pacific·2026
Same author

Publisher Correction: Surviving Sepsis Campaign: international guidelines for management of sepsis and septic shock 2026.

Intensive care medicine·2026

Related Experiment Video

Updated: Jan 31, 2026

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models
07:39

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models

Published on: September 1, 2023

1.9K

How to sharpen a novel sword from AKI basic research.

Kent Doi1

  • 1Department of Acute Medicine, The University of Tokyo, Tokyo, Japan.

Kidney International
|January 5, 2019
PubMed
Summary

Tenascin-C shows protective effects against acute kidney injury. Further research is needed to translate these findings into clinical treatments for patients suffering from kidney damage.

Area of Science:

  • Nephrology
  • Biomedical Research
  • Molecular Biology

Background:

  • Acute kidney injury (AKI) lacks specific treatments, necessitating clinical translation of basic research findings.
  • Improving patient outcomes in AKI requires novel therapeutic strategies.

Purpose of the Study:

  • To investigate the protective role of tenascin-C in acute kidney injury.
  • To explore the potential of tenascin-C as a therapeutic target for AKI.

Main Methods:

  • Utilized animal models to study tenascin-C's effect on AKI.
  • Conducted in vitro and ex vivo experiments to validate findings.

Main Results:

  • Tenascin-C demonstrated a protective effect against acute kidney injury.

More Related Videos

Noninvasive In Vivo Small Animal MRI and MRS: Basic Experimental Procedures
12:27

Noninvasive In Vivo Small Animal MRI and MRS: Basic Experimental Procedures

Published on: October 20, 2009

16.7K
Basic Caenorhabditis elegans Methods: Synchronization and Observation
11:34

Basic Caenorhabditis elegans Methods: Synchronization and Observation

Published on: June 10, 2012

49.4K

Related Experiment Videos

Last Updated: Jan 31, 2026

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models
07:39

Author Spotlight: Investigating the Effects of Compounds on Intestinal Tissue Using 3D Human Cell Line Models

Published on: September 1, 2023

1.9K
Noninvasive In Vivo Small Animal MRI and MRS: Basic Experimental Procedures
12:27

Noninvasive In Vivo Small Animal MRI and MRS: Basic Experimental Procedures

Published on: October 20, 2009

16.7K
Basic Caenorhabditis elegans Methods: Synchronization and Observation
11:34

Basic Caenorhabditis elegans Methods: Synchronization and Observation

Published on: June 10, 2012

49.4K
  • Experimental evidence supports tenascin-C's role in mitigating kidney damage.

    • Conclusions:

    • Tenascin-C presents a promising therapeutic target for acute kidney injury.
    • Overcoming translational barriers is crucial for developing tenascin-C-based AKI therapies.