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IMPLICATION OF RELATIONSHIP BETWEEN OXIDATIVE STRESS AND ANTIOXIDANT STATUS IN BLOOD SERUM
T Kajaia1, L Maskhulia1, K Chelidze1
1Tbilisi State Medical University, Georgia.
Georgian Medical News
|January 9, 2019
Summary
Overtraining syndrome in athletes is linked to increased oxidative stress and a disbalance in antioxidant capacity. Rest helps improve oxidative status, but prolonged imbalances may cause overtraining.
Area of Science:
- Sports Medicine
- Exercise Physiology
- Biochemistry
Background:
- Overtraining syndrome (OTS) and non-functional overreaching (NFO) are critical concerns in highly trained athletes.
- Oxidative stress, an imbalance between reactive oxygen species production and antioxidant defenses, is implicated in OTS.
- Evaluating serum oxidative and antioxidant markers can elucidate the physiological impact of overtraining.
Purpose of the Study:
- To investigate the relationship between oxidative stress markers and the presence of NFO/OTS in athletes.
- To assess changes in serum oxidative and antioxidant status following periods of rest in athletes with and without NFO/OTS.
Main Methods:
- Serum diacron-reactive oxygen metabolites (d-ROMs) and biological antioxidant potential (BAP) were measured in 43 athletes with NFO/OTS and 40 control athletes (CA).
- Measurements were taken at baseline, after 28 days of rest, and after an additional two months of rest for athletes with suspected OTS.
- The ratio of d-ROMs to BAP was used as a marker of oxidative stress.
Main Results:
- Athletes with NFO/OTS exhibited higher baseline d-ROMs and lower BAP compared to CA.
- A 28-day rest period significantly decreased d-ROMs and normalized antioxidant status in NFO athletes.
- Three months of rest improved oxidative status in OTS athletes, but antioxidant capacity remained subnormal with a decreased BAP/d-ROM ratio.
Conclusions:
- Increased oxidative stress, characterized by elevated d-ROMs and reduced BAP, is evident in athletes experiencing overtraining.
- A prolonged imbalance between oxidant production and antioxidant capacity, with attenuated antioxidant defenses, may contribute to OTS.
- Wrestling showed a high prevalence of NFO/OTS, warranting further investigation and regular medical monitoring in this sport.
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