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COMPARISON OF THE OSCILLOMETRICALLY MEASURED AORTIC PULSE WAVE VELOCITY, AUGMENTATION INDEX AND CENTRAL SYSTOLIC

Z Lominadze1, K Chelidze2, L Chelidze3

  • 11LTD Clinic-LJ. Kutaisi Georgia.

Georgian Medical News
|November 8, 2021
PubMed

Insights

Arterial stiffness parameters, including Aortic Pulse Wave Velocity (PWVao), are strong independent markers for Acute Coronary Syndrome (ACS). These measurements can aid in early risk stratification and prevention strategies for ACS.

Area of Science:

  • Cardiology
  • Vascular Physiology
  • Biomedical Engineering

Background:

  • Coronary Artery Disease (CAD) severity is linked to arterial stiffness.
  • Carotid-femoral (cfPWV) and brachial-ankle (baPWV) Pulse Wave Velocity are commonly used.
  • Oscillometric PWVao is an emerging independent marker for atherosclerotic cardiovascular disease (ASCVD).

Purpose of the Study:

  • To compare oscillometrically measured aortic stiffness parameters between Acute Coronary Syndrome (ACS) and stable ischemic heart disease (SIHD) patients.
  • To evaluate the association of these parameters with ACS incidence.

Main Methods:

  • Arterial stiffness was assessed using oscillometrically measured complex arterial function.
  • 100 ACS patients (Group 1) and 91 SIHD patients (Group 2) were included.
  • Parameters measured included Aortic Pulse Wave Velocity (PWVao), Augmentation Index (AIx), and Central Systolic Blood Pressure (SBPao).

Main Results:

  • Aortic Pulse Wave Velocity (PWVao) showed the strongest association with ACS incidence (OR=9.41).
  • Augmentation Index (AIx) was also significantly associated with ACS (OR=5.11).
  • Central Systolic Blood Pressure (SBPao) demonstrated a notable association with ACS (OR=3.15).

Conclusions:

  • Oscillometrically measured arterial stiffness parameters (PWVao, AIx, SBPao) are associated with ACS.
  • These parameters may serve as valuable tools for early risk stratification of ACS.
  • Utilizing these markers can contribute to the prevention of Acute Coronary Syndrome.

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