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[THE STATUS OF VITAMIN В UNDER DISEASES OF SMALL INTESTINE IN CHILDREN IN THE ZONE OF INCREASED SUN INSOLATION]

N R Alieva, A T Kamilova, A N Aripov

    Klinicheskaia Laboratornaia Diagnostika
    |January 9, 2019
    PubMed

    Insights

    Children with small intestine diseases often have low vitamin D levels, especially those with celiac disease or chronic post-infectious enterocolitis. Vitamin D deficiency correlates with calcidiol, parathormone, and alkaline phosphatase levels.

    Area of Science:

    • Pediatric Gastroenterology
    • Clinical Biochemistry
    • Nutritional Science

    Background:

    • Diseases of the small intestine in children can significantly impact nutrient absorption and metabolism.
    • Vitamin D deficiency is a growing concern in pediatric populations, particularly those with gastrointestinal disorders.
    • Understanding the relationship between vitamin D status and specific small intestine diseases is crucial for effective management.

    Purpose of the Study:

    • To investigate the clinical laboratory parallels of vitamin D levels in children diagnosed with various small intestine diseases.
    • To determine the prevalence of vitamin D deficiency across different pediatric enteropathies.
    • To explore the correlations between vitamin D levels and key biochemical markers.

    Main Methods:

    • A cohort of 160 children with small intestine diseases (celiac disease, chronic post-infectious enterocolitis, allergic enterocolitis) and 31 healthy controls were studied.
    • Standard clinical, para-clinical, and instrumental investigations were employed.
    • Levels of calcidiol and parathormone were measured to assess vitamin D status and related hormonal feedback.

    Main Results:

    • A high prevalence of vitamin D deficiency (96.9%) was observed in children with small intestine diseases, reaching 100% in celiac disease and chronic post-infectious enterocolitis groups.
    • Significant correlations were found between vitamin D levels and calcidiol, parathormone, and alkaline phosphatase activity across all patient groups.
    • Lower vitamin D levels were consistently associated with elevated calcidiol, parathormone, and alkaline phosphatase, particularly in celiac disease and chronic post-infectious enterocolitis.

    Conclusions:

    • Vitamin D deficiency is highly prevalent in children suffering from celiac disease, chronic post-infectious enterocolitis, and allergic enterocolitis.
    • The study establishes a clear feedback relationship between vitamin D levels and markers of bone and mineral metabolism in these pediatric conditions.
    • Monitoring vitamin D status and related biochemical parameters is essential for managing children with small intestine diseases.

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