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Single nucleotide polymorphism in the 3' untranslated region of LPP is a risk factor for lung cancer: a case-control
Shouchun Yan1,2, Rong Sun3, Shan Wu4
1Department of Respiratory Medicine, The First Affiliated Hospital of School of Medicine of Xi'an Jiaotong University, Xi'an, 710061, Shaanxi, China.
Background:
Single nucleotide polymorphisms (SNPs) in 3'-untranslated region (UTR) of genes related with cell-matrix adhesions and migration might affect miRNA binding and potentially affect the risk of cancer. The present study aimed to screen SNPs in 3' UTR of cancer-related genes and investigate their contribution to the susceptibility of lung cancer.
Methods:
Seven SNPs were selected and genotyped in a case-control study (322 lung cancer patients and 384 controls) among Chinese Han population. Odds ratio (OR) and 95% confidence intervals (CIs) were calculated by logistic regression adjusted for age and gender in multiple genetic models.
Results:
In stratified analyses by gender, three (rs1064607, rs3796283 and rs2378456) of LPP gene were associated with a significantly increased susceptibility for lung cancer among male population. Besides, LPP rs2378456 weakened lung cancer risk in female. LPP rs1064607 polymorphism was significantly correlated with increased risk of lung adenocarcinoma. Furthermore, AA genotype of TNS3 rs9876 polymorphism was associated with lymphatic metastasis.
Conclusion:
Our results provides evidence for the impact of LPP polymorphisms on the susceptibility to lung cancer in Chinese population.