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[Virologic considerations in donor selection for allogeneic keratoplasty]
A A Bialasiewicz1, G O Naumann, G J Jahn
1Augenklinik mit Poliklinik, Universität Erlangen-Nürnberg.
Klinische Monatsblatter Fur Augenheilkunde
|June 1, 1988
Summary
Screening potential cornea donors for infectious diseases like HIV and Hepatitis B is crucial. This study found infections in clinically normal donors, highlighting the need for thorough donor evaluation.
Area of Science:
- Ophthalmology
- Infectious Disease Screening
- Transplantology
Context:
- Evaluation of 152 potential cornea donors between October 1985 and December 1986.
- Focus on screening for human immunodeficiency virus (HIV) and hepatitis B surface antigen (HBsAg).
- Identification of infectious agents in clinically normal donors.
Purpose:
- To assess the prevalence of HIV and HBsAg in potential cornea donors.
- To determine the necessity of infectious disease screening in cornea donation programs.
- To advocate for interdisciplinary approaches in donor evaluation.
Summary:
- Three clinically normal donors tested positive for HIV (two via ELISA, one via Western Blot).
- Two HIV-positive donors had histories of blood transfusions; one was identified as homosexual.
- Four potential donors showed positive hepatitis B serology.
Impact:
- Highlights the risk of transmitting infectious diseases through organ transplantation.
- Emphasizes the importance of comprehensive infectious disease screening for all potential organ donors.
- Supports the integration of infectious disease protocols into routine donor work-ups.