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Updated: Jan 31, 2026

Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
Anti-GAD Antibody-associated Syndrome Presenting with Limb Myoclonus
Pedro Manzke1,2, Talyta Grippe1,2, Georgia L Tavares1
1Department of Neurology, Instituto Hospital de Base do Distrito Federal, Brasília, BR.
Background:
The clinical spectrum of anti-glutamic acid decarboxylase (GAD) antibody-associated neurologic syndromes is expanding, with focal, generalized, and atypical forms.
Case Report:
We describe a 59-year-old female showing continuous right lower limb myoclonus and mild encephalopathy. These symptoms started 2 weeks prior to evaluation. The patient had great improvement with intravenous steroids. An autoantibody panel was positive for anti-GAD.
Discussion:
Various clinical manifestations, including myoclonus, may relate to anti-GAD antibodies. The treatment options available include symptomatic drugs, intravenous immunoglobulin, steroids, and other immunosuppressant agents.
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