A "Connexin" Responsible for the Fatal Attraction of Cancer to Bone
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David L Waning1, Theresa A Guise2, Khalid S Mohammad2
1Penn State College of Medicine, Department of Cellular and Molecular Physiology and Penn State Cancer Institute, Hershey, PA, USA.
Cell Metabolism
|January 10, 2019
Abstract:
Tumor cell interactions with the bone microenvironment are vital for the establishment and progression of bone metastases. Recently in Cancer Cell, Wang et al. (2018) showed that cells of the osteoblast lineage are critical for the delivery of calcium to tumor cells through gap junctions, pointing toward potential therapies for bone metastases.