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Semaphorin 3A Negatively Affects Proliferation of Mouse Thymus Epithelial Cells In Vitro

K V Rutto1, K S Ovsyukov2, I V Kudryavtsev2

  • 1Institute of Experimental Medicine, St. Petersburg, Russia. krispins-90@mail.ru.

Bulletin of Experimental Biology and Medicine
|January 11, 2019
PubMed
Summary

Semaphorin 3A inhibits thymus epithelial cell proliferation, while hepatocyte growth factor (HGF) and keratinocyte growth factor (KGF) stimulate it. Semaphorin 3A can counteract HGF and KGF effects, impacting thymus restoration therapies.

Keywords:
hepatocyte growth factor (HGF)keratinocyte growth factor (KGF)proliferationsemaphorin 3Athymus epithelial cells

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