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Updated: Jan 30, 2026

Evaluation of Right Ventricular Function in Experimental Models of Pulmonary Arterial Hypertension
Published on: June 27, 2025
[Arterial hypertension : novelties in 2018]
Michel Burnier1, Grégoire Wuerzner1
1Service de néphrologie et hypertension, CHUV, 1011 Lausanne.
Insights
The 2018 European hypertension guidelines emphasize out-of-office measurements, dual-pill therapies, and better adherence. They also cover orthostatic hypotension and hydrochlorothiazide
Area of Science:
- Cardiology
- Hypertension Management
- Pharmacotherapy
Background:
- The 2018 European guidelines for adult hypertension management introduced significant updates.
- Previous management strategies are being revised based on new evidence and therapeutic approaches.
Purpose of the Study:
- To summarize key changes in the 2018 European hypertension guidelines.
- To highlight new recommendations for blood pressure measurement, pharmacotherapy, and patient adherence.
- To discuss specific guidelines for orthostatic hypotension and emerging concerns regarding hydrochlorothiazide use.
Main Methods:
- Review of the 2018 European Society of Cardiology (ESC) and European Society of Hypertension (ESH) guidelines.
- Analysis of new therapeutic concepts and recommendations.
- Inclusion of recent research on specific drug-related risks.
Main Results:
- Increased emphasis on out-of-office blood pressure monitoring.
- Recommendation for dual combination therapy as first-line treatment for most hypertensive patients.
- Promotion of single-pill combinations for improved adherence.
- Inclusion of guidelines for orthostatic hypotension management.
- Discussion of skin cancer risk associated with long-term hydrochlorothiazide use.
Conclusions:
- The updated guidelines promote a more proactive and patient-centered approach to hypertension management.
- New strategies aim to improve blood pressure control, medication adherence, and patient safety.
- Healthcare providers should integrate these updated recommendations into clinical practice.
Abstract:
2018 is the year of the publication of the new European guidelines regarding the management of adult patients with hypertension. These guidelines present several new concepts including a wider use of out-of-office blood pressure measurements, the prescription of dual combinations as first line therapy for most hypertensive patients, a wider use of single pill combinations and a more sustained control of drug adherence with healthcare partners. This article also discusses the new guidelines for the prevention and treatment of orthostatic hypotension and the recently published papers on the risk of skin cancers associated with the long-term use of hydrochlorothiazide (> 5 years).
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