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The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
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Cholangio-Conundrum: A Case Series of Painless Jaundice

Adam P Johnson1, Deviney A Rattigan1, Michael J Pucci1

  • 1Department of Surgery, The Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania.

Case Reports in Pancreatic Cancer
|January 12, 2019
PubMed

Insights

Diagnosing painless jaundice preoperatively is difficult, even with advanced tests. Surgical exploration may be needed for a definitive diagnosis of hepatobiliary and pancreatic diseases.

Area of Science:

  • Hepatobiliary surgery
  • Gastroenterology
  • Surgical oncology

Background:

  • Preoperative diagnosis of hepatobiliary diseases presents challenges despite advancements in imaging and laboratory tests.
  • Distinguishing between benign and malignant causes of painless jaundice is often complex.

Observation:

  • Case 1: A 65-year-old female with painless jaundice and weight loss had Mirizzi syndrome.
  • Case 2: A 71-year-old female with painless jaundice and impacted gallbladder neck stone was diagnosed with cholangiocarcinoma.
  • Case 3: A 70-year-old male with progressive painless jaundice and weight loss had pancreatic adenocarcinoma.

Findings:

  • Painless jaundice can stem from various conditions, including Mirizzi syndrome, cholangiocarcinoma, and pancreatic adenocarcinoma.
  • Clinical presentations of these conditions can overlap, complicating preoperative assessment.

Implications:

  • Accurate preoperative diagnosis for painless jaundice is crucial for appropriate management.
  • Surgical exploration may be necessary to achieve a definitive diagnosis and guide treatment strategies.
  • This highlights the need for a high index of suspicion and potentially invasive diagnostic measures.

Keywords:
Mirizzi syndromecholangiocarcinomapainless jaundicepancreatic cancer

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