Related Experiment Video
Updated: Jan 30, 2026

In Vitro Synthesis of Modified mRNA for Induction of Protein Expression in Human Cells
Published on: November 13, 2014
Synthesis of C3-C21 Segment of Aflastatin A Using Remote Asymmetric Induction Reactions
Sawato Murakoshi1, Seijiro Hosokawa1
1Department of Applied Chemistry, Faculty of Science and Engineering , Waseda University , 3-4-1 Ohkubo , Shinjuku-ku, Tokyo 169-8555 , Japan.
Abstract:
The C3-C21 segment of aflastatin A has been synthesized by converging three segments including the C3-C8 segment, the C9-C15 segment, and the C16-C21 segment. Each segment has been synthesized from a vinylketene silyl N,O-acetal possessing a chiral auxiliary by a wide-range stereocontrol strategy. The C3-C8 segment was constructed in seven steps including the stereoselective vinylogous Mukaiyama alkylation, while the C9-C15 segment and the C16-C21 segment were synthesized using the vinylogous Mukaiyama aldol reaction in seven and eight steps, respectively.
Related Concept Videos
Synthesis and Decomposition Reactions
Rotation of Asymmetric Top
The relationship between the angular momentum of any rigid body and its angular velocity, both of which are vectors, involves the moment of inertia. The moment of inertia is a scalar quantity only for spherically symmetric...
Asymmetric Lipid Bilayer
Reaction Stoichiometry
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction
Dehydration Synthesis
Dehydration synthesis (also called a condensation reaction) is the chemical process in which two molecules covalently link together to form a new molecule, along with the release of a water molecule. Many physiologically important compounds form by dehydration synthesis reactions, such as complex carbohydrates, proteins, DNA, and RNA.
Synthesis of carbohydrates
Sugar molecules are covalently linked together by dehydration synthesis. During the reaction, the hydroxyl (-OH) group from...

