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ncRNA Editing: Functional Characterization and Computational Resources.

Giovanni Nigita1, Gioacchino P Marceca2,3, Luisa Tomasello2

  • 1Department of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA. Giovanni.Nigita@osumc.edu.

Methods in Molecular Biology (Clifton, N.J.)
|January 13, 2019
PubMed
Summary
This summary is machine-generated.

RNA editing modifies noncoding RNAs (ncRNAs), impacting gene regulation and disease. Understanding these modifications is crucial for biological research and developing new therapies.

Keywords:
3′UTRA-to-I RNA editingBioinformaticsIntronsNGSlncRNAmiRNAncRNA editing

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Area of Science:

  • Molecular Biology
  • Genomics
  • Bioinformatics

Background:

  • Noncoding RNAs (ncRNAs) are key regulators of gene expression and cellular processes.
  • Small ncRNAs (sncRNAs) and long ncRNAs (lncRNAs) have distinct regulatory roles.
  • RNA editing dynamically alters RNA sequences, influencing RNA function and biogenesis.

Purpose of the Study:

  • To explore the functional significance of RNA editing in ncRNAs.
  • To review current knowledge bases and bioinformatics tools for studying ncRNA editing.

Main Methods:

  • Next-generation sequencing (NGS) for ncRNAome characterization.
  • Bioinformatics approaches for detecting RNA modifications.
  • Analysis of RNA editing in both coding and noncoding transcripts.

Main Results:

  • RNA editing influences ncRNA biogenesis and function.
  • Dysregulation of RNA editing is linked to human diseases.
  • NGS and bioinformatics are essential for ncRNAome analysis.

Conclusions:

  • ncRNA editing is a critical regulatory mechanism with implications for human health.
  • Available bioinformatics resources facilitate the investigation of ncRNA editing.
  • Further research into ncRNA editing can uncover new therapeutic targets.