Related Experiment Video

Updated: Jan 30, 2026

miRNA Expression Analyses in Prostate Cancer Clinical Tissues
11:29

miRNA Expression Analyses in Prostate Cancer Clinical Tissues

Published on: September 8, 2015

11.2K

Prostate-specific membrane antigen radioligand therapy of prostate cancer

Mohsen Beheshti1,2, Alexander Heinzel3, Dirk von Mallek3

  • 1Department of Nuclear Medicine, University Hospital, RWTH University, Aachen, Germany - mbeheshti@ukaachen.de.

The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [And] the International Association of Radiopharmacology (IAR), [And] Section of the Society Of
|January 16, 2019
PubMed

Insights

Prostate-specific membrane antigen (PSMA) targeted radionuclide therapy offers a promising treatment for advanced prostate cancer. This review covers PSMA characteristics, clinical outcomes, and safety of beta or alpha radiation therapies.

Area of Science:

  • Oncology
  • Nuclear Medicine
  • Radiopharmaceutical Therapy

Background:

  • Metastatic castration-resistance prostate cancer (mCRPC) presents significant treatment challenges.
  • Conventional therapies have limitations in advanced stages.
  • Prostate-specific membrane antigen (PSMA) is a promising target for novel therapies.

Purpose of the Study:

  • To review the characteristics of PSMA.
  • To summarize the clinical performance of PSMA-targeted radionuclide therapy.
  • To evaluate the safety and toxicity profiles of PSMA-targeted beta or alpha radiation therapy.

Main Methods:

  • Literature review of PSMA-targeted radionuclide therapies.
  • Analysis of clinical data on 177-Lutethium (177Lu) and 225-Actinium (225A) therapies.
  • Assessment of safety and toxicity studies.

Main Results:

  • PSMA-targeted therapies demonstrate significant potential in mCRPC.
  • 177Lu and 225A emitters show varying efficacy and toxicity profiles.
  • Further research is ongoing to optimize treatment protocols.

Conclusions:

  • PSMA-targeted radionuclide therapy is an evolving and important treatment modality for mCRPC.
  • Understanding PSMA characteristics and therapy outcomes is crucial for clinical application.
  • Ongoing research aims to improve patient outcomes and minimize treatment-related toxicities.

More Related Videos

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples07:16

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

14.6K
How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases13:18

How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases

Published on: September 20, 2016

10.2K

Related Concept Videos

Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
8.9K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.6K
Group Therapy01:26

Group Therapy

Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
433
Antigen Presenting Cells01:22

Antigen Presenting Cells

The immune system is a complex network of cells and molecules that protects the body from foreign invaders. T cells, a type of white blood cell, play a crucial role in this process. They recognize and attack foreign substances, such as pathogens, that enter the body.
T cells require the help of antigen-presenting cells (APCs), which process foreign antigens into smaller fragments that can be recognized by T cells. These APCs are highly specialized cells that efficiently internalize antigens...
3.2K
Specific Heat01:16

Specific Heat

The specific heat capacity of a substance refers to the energy required to increase the temperature of one gram of that substance by one degree Celcius. Specific heat capacity is often represented in calories (cal), grams (g), and degrees Celsius (oC), but can also be expressed in joules (J), kilograms (kg), and Kelvin (K), among other units.
For example, increasing the temperature of one gram of water by 1°C requires one calorie of heat energy and can be written as 1 cal/g-°C, or...
67.4K