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Gelatin tannate versus other antidiarrheal medication in children with acute gastroenteritis: a retrospective,

Elena D Serban1, Mihai Manolache2

  • 12nd Department of Pediatrics, 'Iuliu Hatieganu' University of Medicine & Pharmacy, Emergency Clinical Hospital for Children, Cluj-Napoca, Romania.

Journal of Comparative Effectiveness Research
|January 16, 2019
PubMed

Insights

Gelatin tannate (GT) effectively treats acute gastroenteritis (AGE) in children. This study found GT significantly reduced diarrhea duration and improved stool consistency compared to other treatments.

Area of Science:

  • Pediatrics
  • Gastroenterology
  • Pharmacology

Background:

  • Acute gastroenteritis (AGE) is a common childhood illness.
  • Effective and safe treatments for pediatric AGE are crucial.

Purpose of the Study:

  • To assess the efficacy and safety of gelatin tannate (GT) in treating acute gastroenteritis (AGE) in children.
  • To compare GT with conventional antidiarrheal medications for pediatric AGE management.

Main Methods:

  • A retrospective observational study involving children aged 6 months to 7.9 years with AGE.
  • Patients received either gelatin tannate (GT) with oral rehydration solution (ORS) or other antidiarrheal medications with ORS.
  • Stool frequency and consistency were primary outcome measures.

Main Results:

  • Gelatin tannate (GT) significantly reduced diarrhea duration compared to other antidiarrheal medications (29.0 vs 45.4 hours, p < 0.0001).
  • GT normalized stool consistency in a higher percentage of patients within 72 hours (87.0% vs 30.4%, p = 0.026).
  • Beneficial effects of GT were observed as early as 12 hours into treatment.

Conclusions:

  • Gelatin tannate (GT) demonstrates superior effectiveness in managing acute gastroenteritis (AGE) in pediatric patients.
  • GT offers a more effective therapeutic option compared to conventional antidiarrheal treatments for children with AGE.
Abstract

Keywords:
acute gastroenteritisantidiarrhealschildrengelatin tannateinfants

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