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Histopathological Prognostic Factors in Clear Cell Renal Cell Carcinoma
B C Andreiana1, A E Stepan2, C Mărgăritescu2
1PhD student, Department of Morphopathology, University of Medicine and Pharmacy of Craiova.
Current Health Sciences Journal
|January 17, 2019
Summary
Clear cell renal cell carcinoma (CCRCC) is most common in men over 58. High Fuhrman grade and mixed patterns indicate aggressive tumors, often linked to advanced stages.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Clear cell renal cell carcinoma (CCRCC) is the predominant subtype of kidney cancer.
- Prognostic factors like Fuhrman grade and tumor stage are critical for patient survival.
- Understanding histopathological features aids in predicting CCRCC behavior.
Purpose of the Study:
- To analyze epidemiological and histopathological characteristics of CCRCC cases.
- To investigate associations between histopathological parameters and tumor stage.
- To evaluate the prognostic value of specific features in CCRCC.
Main Methods:
- Retrospective analysis of 75 CCRCC nephrectomy cases diagnosed between 2014-2017.
- Evaluation of epidemiological data (age, sex) and histopathological features (Fuhrman grade, tumor stage, architectural pattern, sarcomatoid transformation, necrosis).
- Statistical analysis using Chi-Square tests in IBM SPSS software.
Main Results:
- The average age of CCRCC diagnosis was 58.8 years, with a male predominance (66.7%).
- Most cases were stage III (60%) and Fuhrman grade 2 (56%).
- High Fuhrman grade and mixed architectural patterns were significantly associated with advanced tumor stages (p<0.05). Sarcomatoid transformation showed a trend but was not significantly linked to advanced stages.
Conclusions:
- Histopathological parameters are valuable indicators of CCRCC aggressiveness.
- Advanced tumor stages in CCRCC correlate significantly with high Fuhrman grade and mixed architectural patterns.
- These findings support the use of detailed histopathological analysis for CCRCC prognosis.
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