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Minimal clinically important difference of improvement on the Arm Function in Multiple Sclerosis Questionnaire (AMSQ)
Caspar Ep van Munster1, Levent Kaya1, Morgan Obura2
1Department of Neurology, Amsterdam Neuroscience, MS Center Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands.
Multiple Sclerosis (Houndmills, Basingstoke, England)
|January 19, 2019
Summary
This study determined the minimal clinically important difference (MCID) for the Arm Function in Multiple Sclerosis Questionnaire (AMSQ). An MCID of 15 points was identified, aiding in the interpretation of upper extremity function changes in multiple sclerosis patients.
Area of Science:
- Neurology
- Rehabilitation Medicine
- Clinical Measurement
Background:
- The Arm Function in Multiple Sclerosis Questionnaire (AMSQ) is designed to evaluate upper extremity function in individuals with multiple sclerosis (MS).
- A critical gap in the current use of the AMSQ is the absence of a defined minimal clinically important difference (MCID).
Purpose of the Study:
- To establish the minimal clinically important difference (MCID) for the Arm Function in Multiple Sclerosis Questionnaire (AMSQ).
Main Methods:
- A sensitivity- and specificity-based approach was employed.
- A dichotomized global perceived effect served as the anchor for determining the MCID.
- Receiver operating characteristic (ROC) curve analysis was utilized.
Main Results:
- The optimal threshold value identified via the ROC curve was 14.5, with a sensitivity of 0.68 and specificity of 0.79.
- The area under the ROC curve (AUC) was calculated to be 0.77.
- An MCID value of 15 points was determined for the AMSQ, which has a total score range of 31 to 186.
Conclusions:
- The study successfully identified a clinically meaningful threshold for the AMSQ.
- An MCID of 15 points provides a valuable benchmark for interpreting changes in upper extremity function in MS patients using the AMSQ.
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