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Effects of GST null genotypes on individual susceptibility to leukemia: A meta-analysis
Jun Wang1, Depei Wu1, Aining Sun1
1Department of Hematology, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou 215000, China; Institute of Blood and Marrow Transplantation, Collaborative Innovation Center of Hematology, Soochow University, Suzhou 215000, China; Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, Soochow University, Suzhou 215000, China.
Background:
Whether glutathione S-transferases (GST) null genotypes influence individual susceptibility to leukemia remains controversial. Thus, we performed this meta-analysis to better analyze potential influences of GST null genotypes on individual susceptibility to leukemia.
Methods:
Literature retrieve was conducted in PubMed, Web of Science and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.
Results:
Totally fifty-one studies were enrolled for analyses. Significant associations with elevated individual susceptibility to leukemia were detected for GSTM1 (p < .0001, OR = 1.28, 95%CI 1.16-1.41), GSTP1 (p = .003, OR = 1.22, 95%CI 1.07-1.40) and GSTT1 (p < .0001, OR = 1.53, 95%CI 1.35-1.74) null genotypes in overall analyses. Further subgroup analyses by type of disease revealed that GSTM1, GSTP1 and GSTT1 null genotypes were all significantly associated with elevated individual susceptibility to acute lymphoblastic leukemia, GSTM1 and GSTT1 null genotypes were significantly associated with elevated individual susceptibility to acute myeloid leukemia, and GSTT1 null genotype was also significantly associated with elevated individual susceptibility to chronic leukemia. When we stratified data according to ethnicity of participants, positive results were found for all investigated variants in Caucasians and West Asians. Additionally, GSTM1 null genotype was also significantly correlated with elevated individual susceptibility to leukemia in East Asians.
Conclusions:
Our findings indicated that GSTM1, GSTT1 and GSTP1 null genotypes might serve as potential genetic biomarkers of leukemia in certain ethnicities.
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