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Fatigue01:21

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Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
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The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
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The International Collaborative on Fatigue Following Infection (COFFI).

Ben Z Katz1, Simon M Collin2, Gabrielle Murphy3

  • 1Department of Pediatrics, Northwestern University Feinberg School of Medicine, Division of Infectious Diseases, Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, USA.

Fatigue : Biomedicine, Health & Behavior
|January 23, 2019
PubMed
Summary
This summary is machine-generated.

The Collaborative on Fatigue Following Infection (COFFI) is investigating post-infection fatigue (PIF) and its risk factors. Preliminary findings link non-recovery from PIF to lower fitness, female gender, sickness severity, and autonomic dysfunction.

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Area of Science:

  • Infectious Diseases
  • Immunology
  • Epidemiology

Background:

  • Post-infection fatigue (PIF) and related syndromes are poorly understood conditions.
  • The Collaborative on Fatigue Following Infection (COFFI) aims to clarify these conditions.
  • COFFI focuses on homogeneous populations with known infectious triggers.

Purpose of the Study:

  • To foster collaboration among post-infection fatigue (PIF) researchers.
  • To pool data and biosamples for epidemiological and laboratory research.
  • To elucidate the etiology and risk factors for PIF development and progression.

Main Methods:

  • COFFI comprises prospective cohorts from multiple countries (UK, Netherlands, Norway, USA, New Zealand, Australia).
  • Nine closed cohorts include over 3,000 participants with various infections (e.g., infectious mononucleosis, Q fever, giardiasis, campylobacter gastroenteritis).
  • Follow-up periods range from 6 months to 10 years, using Fukuda criteria for chronic fatigue syndrome (CFS) definition.

Main Results:

  • Preliminary analyses identified key risk factors for non-recovery from PIF.
  • Identified risk factors include lower physical fitness, female gender, and severity of the acute sickness response.
  • Autonomic dysfunction was also indicated as a risk factor for persistent fatigue.

Conclusions:

  • COFFI facilitates answering research questions not addressable by individual cohorts.
  • Future research may explore if different infectious triggers lead to distinct PIF syndromes.
  • Longitudinal predictors of PIF and its severity are key areas for future investigation.