Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

The coalescent process in models with selection.

N L Kaplan1, T Darden, R R Hudson

  • 1National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

Genetics
|November 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population genetics of CAPN10 and GPR35: implications for the evolution of type 2 diabetes variants.

American journal of human genetics·2005
Same author

Type I error and the power of the s-test: old lessons from a new, analytically justified statistical test for phylogenies.

Systematic biology·2002
Same author

Power calculations for a general class of tests of linkage and association that use nuclear families with affected and unaffected sibs.

Theoretical population biology·2002
Same author

Analysis of single nucleotide polymorphisms in candidate genes using the pedigree disequilibrium test.

Genetic epidemiology·2002
Same author

Two-locus sampling distributions and their application.

Genetics·2002
Same author

Gene conversion and different population histories may explain the contrast between polymorphism and linkage disequilibrium levels.

American journal of human genetics·2001
Same journal

Coexistence of piRNA and KZFP defense systems: Evolutionary dynamics of layered defense against transposable elements.

Genetics·2026
Same journal

Creation and manipulation of bipartite expression transgenes in C. elegans using phiC31 recombinase.

Genetics·2026
Same journal

Inherited long telomeres induce a genome-wide transcriptional response in budding yeast.

Genetics·2026
Same journal

Adaptive Dynamics of Quantitative Traits in a Steadily Changing Environment.

Genetics·2026
Same journal

Functional Landscape of Zebrafish Gonadotropins and Receptors: A Comprehensive Genetic Analysis.

Genetics·2026
Same journal

Synergistic actions of Nup43 and Myosin VI drive actin cone assembly during Drosophila spermiogenesis.

Genetics·2026
See all related articles

Selection influences gene genealogy. In population genetics, the coalescent process with selection depends on ancestral allele frequencies, impacting neutral mutation analysis and potentially exceeding neutral model predictions.

Area of Science:

  • Population Genetics
  • Molecular Evolution
  • Bioinformatics

Background:

  • The coalescent process models the genealogical history of gene samples.
  • Understanding coalescent dynamics is crucial for interpreting genetic variation.
  • Previous models often assumed selective neutrality, limiting applicability to evolving populations.

Purpose of the Study:

  • To derive statistical properties of the coalescent process in models with selection.
  • To investigate the impact of allele frequency distributions on genealogical history.
  • To calculate the number of segregating sites under selection.

Main Methods:

  • Developed a theoretical framework for coalescent processes with selection.
  • Utilized diffusion approximations for ancestral allele frequency dynamics.

Related Experiment Videos

  • Performed numerical calculations for mean and variance of segregating sites.

    • Main Results:

    • Coalescent process distribution under selection depends on ancestral allele frequencies.
    • Mean and variance of neutral segregating sites can be calculated using diffusion approximations.
    • Tightly regulated allele frequencies simplify calculations.
    • Low mutation rates under balancing selection lead to more segregating sites than neutral models predict.

    Conclusions:

    • Selection significantly alters gene genealogical history compared to neutral models.
    • The coalescent process provides a framework for analyzing genetic variation under selection.
    • Deviations from neutral predictions are expected when selection is present, especially with balancing selection.