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[The correlation between children's serum 25-hydroxyvitamin D and allergic rhinitis in Jiangxi Province]
1Department of OtorhinolaryngologyHead and Neck Surgery, the First Affiliated Hospital of Nanchang University, Nanchang, 330006,China.
Insights
Children with allergic rhinitis (AR) have lower serum 25-hydroxyvitamin D [25(OH)D] levels. While a correlation exists, low vitamin D is not an effective auxiliary diagnostic tool for pediatric AR.
Area of Science:
- Pediatric Allergy and Immunology
- Nutritional Biochemistry
- Epidemiology
Context:
- Allergic rhinitis (AR) is a prevalent condition in children, impacting their quality of life.
- Vitamin D deficiency is a growing global health concern, with potential links to immune function.
- Understanding the interplay between vitamin D and AR in pediatric populations is crucial for public health.
Purpose:
- To investigate the correlation between serum 25-hydroxyvitamin D [25(OH)D] levels and allergic rhinitis (AR) in children.
- To explore the potential role of vitamin D deficiency in the pathogenesis of pediatric AR.
- To assess the diagnostic utility of serum 25(OH)D levels as an auxiliary marker for AR in children.
Summary:
- This study enrolled 76 children with AR and 68 healthy controls from Jiangxi Province, China.
- Serum 25(OH)D levels were significantly lower in children with AR compared to controls (P=0.0008).
- No significant correlation was found between serum 25(OH)D levels and AR severity, gender, eosinophil count, or asthma, and its diagnostic efficiency was low (AUC=0.6614).
Impact:
- The findings suggest a correlation between vitamin D deficiency and AR in children, although vitamin D may not be directly involved in AR pathogenesis.
- Serum 25(OH)D levels are not recommended as an auxiliary diagnostic indicator for clinical AR diagnosis in children.
- This research provides insights into the relationship between vitamin D and pediatric allergic diseases, potentially informing future nutritional interventions.
Abstract:
Objective:We attempt to investigate the correlation between serum 25-hydroxyvitamin D［25(OH)D］ level and allergic rhinitis(AR) of children in Jiangxi Province,for providing new clues for the pathogenesis of AR in children.Method:Seventy-six AR children and 68 healthy controls from various counties and cities of Jiangxi Province were enrolled. All subjects recepted questionnaire survey, allergen skin prick test,serum specific IgE test,serum 25(OH)D test and routine blood test. AR children completed the visual analogue scale(VAS) scores and rhinoconjunctivitis quality of life questionnaire(RQLQ) scores.Result:The mean body mass index(BMI) of AR children in Jiangxi Province was significantly lower than that of healthy peers (P<0.000 1),but there was no correlation between BMI and serum 25(OH)D level.Serum 25(OH)D level of AR children was signtificantly lower,compared to the conrtols (P=0.0008),while the area under the receiver operating characteristic curve(AUC)of subjects was 0.6614, That is,serum 25(OH)D was not an efficient auxiliary diagnosis in AR children.Serum 25(OH)D level of AR children was not correlated with the severity, gender,peripheral blood eosinophils and asthma.Conclusion:AR can affect the growth and development of children.Children's serum 25(OH)D deficiency was correlated to AR, but its efficiency for auxiliary diagnosis in AR is not high.So it cannot be used as an auxiliary indicator for clinical diagnosis of AR.Serum 25(OH)D may not be directly involved in the pathogenesis of children's AR.