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Updated: Jan 30, 2026
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Ultrasound Cyclo Plasty in Eyes with Glaucoma
Published on: January 26, 2018
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[The diagnostic and prognostication of glaucoma.]
1The Krasnodar Branch of the Federal State Self-Contained Institution "The S.N. Fedorov Interbranch Scientific and Technical Complex "Eye Microsurgery"" of Minzdrav of Russia, 350012, Moscow, Russia.
Klinicheskaia Laboratornaia Diagnostika
|January 25, 2019
Summary
Glaucoma, a leading cause of blindness, may be diagnosed and prognosticated using specific interleukin (IL) levels in tears. This study highlights IL-2, IL-17, and IL-8 as key biomarkers for glaucoma detection.
Area of Science:
- Ophthalmology
- Immunology
- Biomarker Discovery
Background:
- Glaucoma is a primary cause of irreversible blindness globally, with increasing patient numbers projected.
- Alterations in the interleukin profile within lacrimal fluid are associated with glaucoma development.
- The diagnostic value of specific interleukins in glaucoma remains insufficiently explored.
Purpose of the Study:
- To ascertain the diagnostic significance of local interleukins in lacrimal fluid.
- To improve glaucoma diagnosis and prognostication through local interleukin analysis.
Main Methods:
- Sandwich-linked enzyme-linked immunosorbent assay (ELISA) was employed to quantify interleukin content in lacrimal fluid.
- Analysis included 80 patients with stage II glaucoma and 45 healthy controls.
- Informativeness of immune indices was calculated to assess diagnostic utility.
Main Results:
- Interleukin-2 (IL-2), Interleukin-17 (IL-17), and Interleukin-8 (IL-8) demonstrated high diagnostic significance for glaucoma verification.
- Elevated levels of IL-2, IL-17, and IL-8 were identified as key indicators.
- A developed regression model accurately prognosticated glaucoma development based on these interleukin levels.
Conclusions:
- IL-2, IL-17, and IL-8 are proposed as valuable biomarkers for laboratory diagnosis and prognostication of glaucoma.
- These interleukins offer a promising avenue for early detection and management of glaucoma.
- The findings support the integration of local interleukin analysis into clinical glaucoma assessment.
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