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Updated: Jan 30, 2026

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
Published on: September 6, 2019
A one-pot, water compatible synthesis of pyrimidine nucleobases under plausible prebiotic conditions
Hidenori Okamura1, Sidney Becker, Niklas Tiede
1Center for Integrated Protein Science (CiPSM) at the Department of Chemistry, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377 München, Germany. thomas.carell@lmu.de.
Abstract:
Herein, we report a new prebiotically plausible pathway towards a pyrimidine nucleobase in continuous manner. The route involves simultaneous methylation and carbamoylation of cyanoacetylene-derived α,β-unsaturated thioamide with N-methyl-N-nitrosourea (MNU) in aqueous media. This provides S-methylpyrimidinone in one-pot, which can be converted into a variety of 4-substituted pyrimidine nucleobases including cytosine and uracil.
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