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Related Concept Videos

Cancer02:18

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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What is Cancer?02:12

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Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
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Cancer Prevention02:59

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Skin Cancer01:30

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Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
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Vulvar Cancer.

Daniel Weinberg1, Ricardo A Gomez-Martinez1

  • 1Department of Obstetrics and Gynecology, University of New Mexico, MSC10 5580, 1 University of New Mexico, Albuquerque, NM 87131, USA.

Obstetrics and Gynecology Clinics of North America
|January 27, 2019
PubMed
Summary
This summary is machine-generated.

This review covers vulvar preinvasive lesions, squamous cell carcinoma, and melanoma, focusing on diagnosis and management. Key updates include sentinel lymph node dissection for early stages and chemoradiation for advanced vulvar cancer.

Keywords:
ChemotherapyMelanomaPaget diseaseRadiationSquamous cell carcinomaSurgeryVulvar cancer

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Area of Science:

  • Gynecologic Oncology
  • Dermatologic Surgery
  • Oncologic Imaging

Background:

  • Vulvar cancer encompasses preinvasive lesions, squamous cell carcinoma, and melanoma, requiring comprehensive management strategies.
  • Epidemiology and diagnostic approaches are crucial for timely intervention in vulvar malignancies.
  • Current therapeutic advancements impact both early and late-stage vulvar disease.

Purpose of the Study:

  • To provide an updated review of the epidemiology, diagnosis, and management of vulvar preinvasive lesions, squamous cell carcinoma, and melanoma.
  • To highlight recent advances in surgical and oncological treatments for vulvar cancer.
  • To include a review of vulvar Paget disease.

Main Methods:

  • Literature review of epidemiological data, diagnostic criteria, and treatment modalities for vulvar lesions.
  • Emphasis on sentinel lymph node dissection techniques and outcomes for early-stage vulvar cancer.
  • Review of current chemoradiation protocols for advanced-stage vulvar cancer.

Main Results:

  • Sentinel lymph node dissection is a key strategy for staging early-stage vulvar squamous cell carcinoma.
  • Advances in chemoradiation offer improved outcomes for patients with late-stage vulvar cancer.
  • Vulvar Paget disease management is also briefly discussed.

Conclusions:

  • Optimal management of vulvar lesions requires a multidisciplinary approach integrating surgery, radiation, and chemotherapy.
  • Sentinel lymph node dissection has refined staging and treatment for early vulvar cancer.
  • Chemoradiation represents a significant advancement in treating advanced vulvar cancer, with ongoing research.