Related Experiment Video
Updated: Jan 30, 2026
06:39
Use of Hematopoietic Stem Cell Transplantation to Assess the Origin of Myelodysplastic Syndrome
Published on: October 3, 2018
10.2K
[Staphylococcus aureus toxic shock syndrome originating from a split skin transplant]
Niklas Schurmann Hansen1, Lars Toft Nielsen, Steffen Leth
1niklhans@rm.dk.
Ugeskrift for Laeger
|January 29, 2019
Summary
Toxic shock syndrome, a rare bacterial illness, can arise from Staphylococcus aureus. This case report details a successful recovery in a 75-year-old man following prompt antibiotic and immunoglobulin treatment.
Area of Science:
- Infectious Diseases
- Microbiology
- Immunology
Background:
- Toxic shock syndrome (TSS) is a severe, acute multisystem disease.
- It is primarily caused by exotoxins produced by Staphylococcus aureus or Streptococcus pyogenes.
- Superantigens trigger a cytokine storm, leading to shock.
Observation:
- This report details a case of TSS in a 75-year-old male.
- The infection originated from a split skin transplant.
- Clinical manifestations included rash, conjunctival hyperemia, and skin desquamation.
Findings:
- The patient met all diagnostic criteria for S. aureus TSS.
- Treatment involved antibiotics, immunoglobulins, and supportive care.
- The patient experienced a full recovery.
Implications:
- This case highlights the potential for TSS following skin grafting procedures.
- Early diagnosis and comprehensive treatment are crucial for patient outcomes.
- Understanding the role of bacterial exotoxins in TSS pathogenesis is vital.
Related Concept Videos
01:16Shock Waves
2.5K
While deriving the Doppler formula for the observed frequency of a sound wave, it is assumed that the speed of sound in the medium is greater than the source's speed through it. When this condition is breached, a shock wave occurs.
When the source's speed approaches the speed of sound, constructive interference between successive wavefronts emitted by the source occurs immediately behind it. Initially, scientists believed that this constructive interference would result in such high...
When the source's speed approaches the speed of sound, constructive interference between successive wavefronts emitted by the source occurs immediately behind it. Initially, scientists believed that this constructive interference would result in such high...
2.5K
01:13¹H NMR: Complex Splitting
1.9K
A proton M that is coupled to a proton X results in doublet signals for M. However, NMR-active nuclei can be simultaneously coupled to more than one nonequivalent nucleus. When M is coupled to a second proton A, such as in styrene oxide, each peak in the doublet is split into another doublet.
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied...
Splitting diagrams or splitting tree diagrams are routinely used to depict such complex couplings. While drawing splitting diagrams, the splitting with the larger coupling constant is usually applied...
1.9K
01:26Toxic Reactions: Overview
2.0K
When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...
2.0K
02:21Cancers Originate from Somatic Mutations in a Single Cell
14.9K
Cancer arises from mutations in the critical genes that allow healthy cells to escape cell cycle regulation and acquire the ability to proliferate indefinitely. Though originating from a single mutation event in one of the originator cells, cancer progresses when the mutant cell lines continue to gain more and more mutations, and finally, become malignant. For example, chronic myelogenous leukemia (CML) develops initially as a non-lethal increase in white blood cells, which progressively...
14.9K
01:13¹H NMR Signal Multiplicity: Splitting Patterns
6.9K
When protons A and X are coupled, their nuclear spin energy levels are slightly modified. This is because the energy required to excite proton A to a spin state parallel to proton X is slightly different from the energy required for it to become anti-parallel to spin X. Consequently, there are two possible excitation frequencies for A (A1 and A2), depending on the spin state of X, and vice versa. The mutual nature of coupling implies that the difference between frequencies A1 and A2, indicated...
6.9K
01:24Blood Pressure Imbalances and Circulatory Shock
1.7K
Disorders affecting blood volume, vascular tone, or vascular function can disrupt vascular homeostasis, including conditions like hypertension, hemorrhage, and shock.
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
Blood Pressure: Hypertension and Hypotension
Normal blood pressure is 120/80 mm Hg. Elevated blood pressure is 120-129/under 80 mm Hg. Hypertension, warranting treatment at 130/80 mm Hg, is often asymptomatic and can lead to severe cardiovascular events, aneurysms, peripheral arterial disease, chronic renal disease, or cardiac...
1.7K