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Prediction effects of serum CA125 decrease ratio during different cycles in relapsed ovarian cancer.

Jieyu Wang1,2, Yuantao Liu1,2, Jun Li1,2

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The Journal of Obstetrics and Gynaecology Research
|January 29, 2019
PubMed
Summary
This summary is machine-generated.

A significant decrease in cancer antigen 125 (CA125) levels after chemotherapy may predict longer relapse-free survival in epithelial ovarian cancer (EOC) patients. Monitoring CA125 response can guide treatment and follow-up strategies.

Keywords:
CA125chemotherapyepithelial ovarian cancerrelapse

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Area of Science:

  • Oncology
  • Gynecologic Oncology
  • Biomarkers

Background:

  • Epithelial ovarian cancer (EOC) recurrence is a significant clinical challenge.
  • Serum cancer antigen 125 (CA125) is a widely used biomarker in EOC management.
  • Predicting relapse timing is crucial for optimizing patient care and follow-up strategies.

Purpose of the Study:

  • To evaluate the prognostic significance of serum CA125 levels during chemotherapy in relapsed EOC.
  • To establish CA125 cut-off values for differentiating early (<12 months) from late (>12 months) relapse.
  • To correlate CA125 response with overall survival (OS) in relapsed EOC patients.

Main Methods:

  • Retrospective analysis of 93 relapsed EOC patients treated between 2003 and 2015.
  • Univariate regression analysis to identify prognostic factors.
  • Kaplan-Meier method to assess overall survival (OS) rates.
  • Calculation of CA125 decrease ratio after the fourth chemotherapy cycle.

Main Results:

  • A CA125 decrease ratio >97.6% after four chemotherapy cycles was significantly associated with longer relapse time (P=0.044).
  • This cut-off demonstrated 70.0% sensitivity and 76.9% specificity.
  • Patients with >97.6% CA125 decrease showed significantly better OS (P=0.0019).

Conclusions:

  • A CA125 decrease ratio <97.6% after four chemotherapy cycles predicts relapse within 12 months.
  • Patients with a suboptimal CA125 decrease require intensified follow-up and re-examination.
  • CA125 response monitoring offers valuable prognostic information in relapsed EOC.