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Published on: June 28, 2021
Relationship between an indel mutation within the SIRT4 gene and growth traits in Chinese cattle
Qingfeng Zhang1,2, Yunyun Jin3, Fugui Jiang1,2
1Institute of Animal Science and Veterinary Medicine, Shandong Academy of Agricultural Sciences , Jinan , Shandong , China.
Abstract:
Growth traits are mainly determined by genetic factors. SIRT4, a class II sirtuin, predominantly acts as an ADP-ribosyltransferase and inhibits fatty acid oxidation. In this study, a total of 1005 cattle belonging to five indigenous Chinese breeds were used to evaluate the relationship between the potential insertions/deletions (indels) within the SIRT4 gene and growth traits. The results revealed that only one intronic variation was present, which showed Hardy-Weinberg equilibrium (p > 0.05) in all the populations. The relationship analyses indicated that this indel was significantly associated with growth traits (p < 0.05), implying that SIRT4 significantly affects the growth traits. Therefore, the deletion mutation within the SIRT4 gene could be considered as a molecular marker to screen for growth traits in the cattle industry.
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