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Updated: Jan 30, 2026

Assessing Early Stage Open-Angle Glaucoma in Patients by Isolated-Check Visual Evoked Potential
Published on: May 25, 2020
Posterior pole asymmetry analysis and retinal nerve fibre layer thickness measurements in primary angle-closure
Yi Zha1, Wei Huang2, Jinfei Zhuang1
1Department of Ophthalmology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, 325027, Zhejiang, China.
Purpose:
To measure peripapillary retinal nerve fiber layer (RNFL) thickness and posterior pole retinal thickness in primary angle-closure suspects (PACS) by Spectral domain optical coherence tomography (SD-OCT) and to be compared with normal subjects.
Methods:
Thirty five primary angle-closure suspect patients and thirty normal subjects were enrolled in this study. Peripapillary RNFL and posterior pole retinal thickness by posterior pole asymmetry analysis (PPAA) in SD-OCT were measured.
Results:
No significant difference was found in both groups on age, sex distribution, refractive error, intraocular pressure (IOP) and axial length. The PACS group exhibited significantly thinner macular retinal thickness and larger asymmetry on posterior pole region compared with the control group. Yet no significant difference of peripapillary RNFL parameters was found between PACS group and normal control group. A negative correlation was observed between the total retinal thickness on posterior pole region and age when all the PACS participants were analyzed.
Conclusions:
Posterior pole retinal thickness measurements obtained by Heidelberg Spectralis SD-OCT using PPAA showed significant thinner change in PACS group than healthy controls. Only age seemed to be an indicator in the occurrence of glaucomatous damage in PACS patients.
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