Adding to platelet safety and life: Platelet additive solutions.

Area of Science:

• Transfusion Medicine
• Hematology
• Blood Component Therapy

Background:

• Platelet additive solutions (PAS) are used for platelet storage, replacing a significant portion of plasma.
• PAS reduces the volume of storage plasma in platelet components.
• Platelets stored in PAS are associated with a lower risk of allergic transfusion reactions and maintain clinical efficacy.

Purpose of the Study:

• To evaluate the clinical and laboratory efficacy of platelets stored in PAS (PAS-platelets).

Main Methods:

• Collected 1674 single donor platelets (SDP) in PAS from June to September 2016.
• Performed quality control on 356 units, analyzing ABO antibody titers, volume, platelet count, pH, and bacterial contamination.
• Utilized Amicus, Trima Accel, and MCS+ apheresis systems for SDP processing.

Main Results:

• Significantly reduced Anti-A and Anti-B titers (≤1:32) in PAS-SDP.
• All tested units were negative for bacterial contamination.
• No adverse transfusion reactions were reported for transfused PAS-SDP units.
• Other quality parameters for platelets remained satisfactory.

Conclusions:

• PAS addition significantly reduces ABO antibody titers, facilitating ABO-incompatible SDP transfusions.
• Reduced plasma volume in PAS-SDP units lowers the risk of allergic transfusion reactions.
• PAS-SDP improves platelet inventory management without compromising clinical or laboratory efficacy.