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Norascyronones A and B, 2,3,4- nor-Polycyclic Polyprenylated Acylphloroglucinols from Hypericum ascyron
Ya-Li Hu1,2, Kun Hu1, Ling-Mei Kong1,2
1State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry , Kunming 650201 , People's Republic of China.
Abstract:
Phytochemical study of Hypericum ascyron led to the characterization of norascyronones A-C (1-3), metabolites derived from bicyclic polyprenylated acylphloroglucinols by losing eight carbons (C-2/3/4 of core and the isoprenyl at C-3). Compounds 1/2 with an unprecedented 6/6/5/6 ring system should be generated via [4 + 2] intramolecular cyclization of 3. Their structures were determined by spectroscopic and X-ray diffraction data. Compounds 1 and 2 showed cytotoxicities against the SK-BR-3 cell line (IC50 4.3 and 7.8 μM).
