Related Experiment Video
Updated: Jan 30, 2026
08:11
Measuring Progressive Neurological Disability in a Mouse Model of Multiple Sclerosis
Published on: November 14, 2016
11.6K
[Clinical and radiological outcomes measures in progressive multiple sclerosis]
Juan I Rojas1, Liliana Pattrucco1, Edgardo Cristiano1
1Centro de Esclerosis Múltiple de Buenos Aires, Hospital Italiano de Buenos Aires, Argentina.
Medicina
|January 30, 2019
Summary
Researchers reviewed clinical and imaging tools for tracking progressive multiple sclerosis (MS) activity and disability. Early identification of disease progression in MS is crucial for effective patient management and treatment strategies.
Area of Science:
- Neurology
- Clinical Research
- Medical Imaging
Background:
- Progressive forms of multiple sclerosis (MS) require accurate assessment of disability and inflammatory activity.
- Several instruments have been developed to identify MS activity and progression.
- These tools are widely used in clinical trials but less familiar in routine healthcare practice.
Purpose of the Study:
- To review clinical and imaging evaluation measures for assessing disease activity and evolution in progressive multiple sclerosis.
- To provide an overview of recent advancements in MS assessment tools.
Main Methods:
- Literature review of clinical and imaging evaluation measures.
- Focus on instruments developed for progressive MS phenotypes.
- Analysis of tools used in clinical trials and their potential for healthcare practice.
Main Results:
- A range of clinical and imaging measures have been developed to assess progressive MS.
- These instruments vary in sensitivity for detecting disease activity and progression.
- There is a gap in the routine adoption of these advanced tools by healthcare professionals.
Conclusions:
- Accurate assessment tools are vital for managing progressive MS.
- Further integration of these measures into clinical practice is needed.
- Continued research aims to refine and validate these instruments for better patient outcomes.
Related Concept Videos
01:30Radiological Investigation I: X-ray and CT
1.2K
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
1.2K
02:24Predicting Reaction Outcomes
10.8K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.8K
01:13Outcomes of Glycolysis
107.1K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.1K
02:07Tumor Progression
7.4K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
7.4K
01:11Guidelines for Writing Outcome
3.8K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
3.8K
01:30Radiological Investigation II: MRI and Ventilation Perfusion Scan
593
Description
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
Magnetic Resonance Imaging (MRI) and Ventilation Perfusion Scans are two radiological investigations that offer detailed diagnostic images of the body, particularly lung structures.
MRI
MRI uses magnetic fields and radiofrequency signals to distinguish between normal and abnormal tissues. This technology provides a more detailed diagnostic image than CT scans, enabling it to characterize pulmonary nodules, stage bronchogenic carcinoma, and evaluate inflammatory activity in...
593