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Dissociative Bioorthogonal Reactions.

Julian Tu1, Minghao Xu1, Raphael M Franzini1

  • 1Department of Medicinal Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, Utah, 84112, USA.

Chembiochem : a European Journal of Chemical Biology
|January 30, 2019
PubMed
Summary
This summary is machine-generated.

Dissociative bioorthogonal reactions, which release molecules under physiological conditions, are gaining traction. This review covers their development, applications in drug delivery and diagnostics, and areas needing further research.

Keywords:
bioorthogonal chemistrycleavage reactionscycloadditiondrug deliveryprotecting groups

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Area of Science:

  • Biochemistry
  • Chemical Biology
  • Medicinal Chemistry

Background:

  • Bioorthogonal reactions are crucial tools in life sciences, enabling chemical modifications within biological systems.
  • While ligating reactions are established, dissociative bioorthogonal reactions that release molecules are emerging as a key area of interest.
  • These reactions offer precise control over molecular interactions in complex biological environments.

Purpose of the Study:

  • To review the landscape of bioorthogonal reactions designed for molecular release or linker cleavage.
  • To highlight diverse applications of dissociative bioorthogonal reactions in biological research and medicine.
  • To identify current limitations and future directions for developing advanced release-based bioorthogonal chemistries.

Main Methods:

  • Literature review of published research on dissociative bioorthogonal reactions.
  • Categorization of reactions based on their release mechanisms and triggers.
  • Analysis of application examples in areas like drug delivery, diagnostics, and biological probes.

Main Results:

  • A comprehensive summary of various bioorthogonal reactions enabling molecular release.
  • Demonstration of applications in controlling biomacromolecule activity, targeted drug delivery, and diagnostic assays.
  • Identification of key challenges including reaction kinetics, stability, and in vivo translation.

Conclusions:

  • Dissociative bioorthogonal reactions represent a powerful complementary approach to ligation-based chemistries.
  • These reactions hold significant promise for advancing therapeutic and diagnostic strategies.
  • Further research is needed to optimize reaction efficiency, selectivity, and in vivo applicability for broader adoption.