[FEATURES OF MODIFYING EFFECT OF LOW-INTENSITY ELECTROMAGNETIC RADIATION OF NATURAL AND TECHNOGENIC ORIGIN ON...

Area of Science:

• Electromagnetic radiation effects
• Immunology
• Cell biology

Background:

• Neutrophilic granulocytes play a crucial role in innate immunity.
• Exposure to electromagnetic radiation (EMR) from various sources is increasingly prevalent.
• Understanding the in vitro effects of specific EMR types on immune cells is important for public health.

Purpose of the Study:

• To investigate the in vitro effects of Super High Frequency (SHF) microwave electromagnetic radiation (EMR) on the viability and functional status of neutrophilic granulocytes.
• To compare the effects of natural (broadband) and technogenic (mono-frequency) EMR on neutrophils.

Main Methods:

• Human neutrophils from healthy donors were exposed to SHF EMR (4–4.34 GHz) generated by a SHF-generator.
• Viability, phagocytic activity, lysosome activity, NBT-reducing ability, and cytokine levels (IL1β, TNFα) were assessed 16 minutes post-exposure.
• EMR sources simulated natural radio emissions and technogenic emissions from electronic devices.

Main Results:

• Technogenic EMR significantly reduced the number of viable neutrophils, while their functional status remained unchanged.
• Natural EMR exposure maintained neutrophil viability and led to increased IL1β and TNFα levels in supernatants.
• In women, natural EMR increased phagocytic ability and decreased oxygen radical production; in men, neutrophil function was stable.

Conclusions:

• Technogenic EMR may compromise innate immunity and homeostasis, potentially leading to pathological conditions.
• EMR of natural origin demonstrates potential for prophylactic and clinical applications in medicine.
• Further research into the therapeutic applications of modelled microwave EMR is warranted.