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[MOLECULAR-BIOLOGICAL MARKERS OF HEPATITIS B IN PATIENTS WITH LIVER FIBROSIS/CIRRHOSIS IN UZBEKISTAN]
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|January 30, 2019
Summary
Hepatitis B virus (HBV) genotype D, particularly subtype D1, is highly prevalent (82%) in Uzbekistan among patients with liver disease. This finding is crucial for developing effective HBV prevention and treatment strategies in Central Asia.
Area of Science:
- Hepatology
- Virology
- Genetics
Background:
- Hepatitis B virus (HBV) infection remains a significant global health concern, particularly in Central Asia.
- Understanding HBV genotypes and subtypes is crucial for effective disease management and prevention strategies.
Purpose of the Study:
- To evaluate the prevalence of hepatitis B virus genetic variants in Uzbekistan.
- To analyze HBV genotypes and subtypes in patients with varying degrees of liver fibrosis and cirrhosis.
Main Methods:
- Direct sequencing of the Pre-S1/Pre-S2/S HBV DNA region was used for genotyping.
- Phylogenetic analysis was performed on samples from 39 patients with liver fibrosis and cirrhosis.
Main Results:
- Hepatitis B virus was detected in 82% of the studied samples.
- Only genotype D was identified, with subtype D1 predominating (84.38%), followed by D3 (12.5%) and D2 (3.12%).
Conclusions:
- The study highlights the dominance of HBV genotype D, specifically subtype D1, in the Uzbek population.
- Large-scale HBV sequencing in Central Asia is essential for understanding transmission routes and evolutionary history, aiding in prophylaxis and therapy development.
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