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Updated: Jan 30, 2026

Intranasal Administration of Recombinant Influenza Vaccines in Chimeric Mouse Models to Study Mucosal Immunity
Published on: June 25, 2015
[COMPARATIVE ACTIVITY OF INFLUENZA VACCINES: EFFECT ON LYMPHO- CYTE SUBPOPULATION STRUCTURE]
The immune-adjuvanted Grippol plus vaccine significantly boosted immune cell activity in healthy individuals more than unadjuvanted vaccines. This influenza vaccine enhanced both innate and adaptive immunity markers in vitro.
Area of Science:
- Immunology
- Vaccinology
Background:
- Influenza vaccines are crucial for public health.
- Understanding vaccine-induced immune responses is essential.
Purpose of the Study:
- To investigate the in vitro effects of different influenza vaccines on lymphocyte subpopulations in healthy individuals.
- To compare the immune-stimulating potential of immune-adjuvanted and unadjuvanted influenza vaccines.
Main Methods:
- Peripheral blood mononuclear cells (PBMCs) from healthy individuals were activated in vitro.
- Flow cytometry was used to evaluate immune-phenotype features and cell activation markers.
Main Results:
- Grippol plus (immune-adjuvanted) demonstrated a stronger stimulating effect on NK-cells and early activation markers (CD45/CD25) compared to subunit and split vaccines.
- This vaccine increased natural regulatory cells (CD4/CD25/Foxp3), B-cells, and decreased cells with apoptosis markers (CD45/CD95).
Conclusions:
- The immune-adjuvanted Grippol plus vaccine effectively induces effectors of both innate and adaptive immunity.
- Grippol plus exhibits superior potential in activating diverse immune-competent cells compared to unadjuvanted vaccines.
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