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[SONNEI DYSENTERY MORBIDITY IN KHABAROVSK AND KHABAROVSK REGION DUE TO ATYPICAL MANNITOL-NEGATIVE CAUSATIVE AGENT]

A P Bondarenko, T A Zaitseva, O E Trotsenko

    Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
    |January 30, 2019
    PubMed
    Abstract

    Insights

    Atypical Shigella sonnei strains caused a prolonged dysentery outbreak in Khabarovsk, driven by carrier states. Molecular subtyping revealed a single genotype despite distinct drug resistance patterns, highlighting the need for comprehensive strain analysis.

    Area of Science:

    • Microbiology
    • Epidemiology
    • Public Health

    Background:

    • Sonnei dysentery outbreaks pose a significant public health challenge.
    • Understanding the etiological agents and transmission dynamics is crucial for effective control.

    Purpose of the Study:

    • To characterize the epidemic process of Sonnei dysentery in the Khabarovsk Region between 2012 and 2014.
    • To investigate the features of an atypical causative agent responsible for a prolonged outbreak.

    Main Methods:

    • Isolation and characterization of 161 Shigella sonnei cultures from patients.
    • Biochemical typing, colicin-genotyping, and drug resistance profiling.
    • Molecular subtyping using Pulsed Field Gel Electrophoresis (PFGE).

    Main Results:

    • A prolonged Sonnei dysentery outbreak in a children's boarding house was linked to atypical mannitol-negative Shigella strains.
    • The epidemic was sustained by prolonged carrier states within the patient and staff population.
    • All isolates shared the same colicin-genotype and PFGE genotype, but exhibited two distinct drug resistance clones.

    Conclusions:

    • Atypical Shigella sonnei strains can cause prolonged outbreaks, emphasizing the importance of identifying unusual variants.
    • Prolonged carrier states play a critical role in sustaining infectious disease transmission in institutional settings.
    • Integrated phenotypic and genotypic analyses are essential for accurate characterization and comparison of bacterial isolates during outbreaks.

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