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[ANALYSIS OF POPULATION IMMUNITYAGAINST INFLUENZA PRIOR TO 2014 AND 2015 EPIDEMIC SEASONS]
Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|January 30, 2019
Summary
Population immunity against influenza A(H3N2) in Russia is low. This highlights the critical importance of the upcoming autumn 2016 vaccination campaign for mitigating widespread influenza epidemics.
Area of Science:
- Virology
- Immunology
- Public Health
Background:
- Assessing population immunity is crucial for understanding influenza transmission dynamics.
- Monitoring antibody levels against seasonal and potentially pandemic influenza strains is essential for public health preparedness.
Purpose of the Study:
- To evaluate herd immunity against seasonal influenza viruses in the Russian population.
- To detect antibodies against influenza viruses with pandemic potential in human blood sera.
Main Methods:
- Hemagglutination Inhibition (HAI) assays were performed on human blood sera.
- Antigens included seasonal influenza vaccine strains, epidemic strains, and highly pathogenic avian influenza (HPAI) viruses (A/H5N1 and A/H7N9).
Main Results:
- No reactivity was observed against A/H5N1 and A/H7N9 antigens in sera from 2014-2015.
- Seropositivity rates in 2014 varied: 41% for A/H1N1pdm09, 36% for A/H3N2, and 40-47% for influenza B strains.
- In 2015, seropositivity for A/H3N2 was low (4-13%) except in the Urals Federal District (>30%), and varied for influenza B (23-76%).
- Low percentages of sera (2-10%) showed high antibody titers (≥40) against all tested vaccine strains.
Conclusions:
- Population immunity against influenza A(H3N2) in Russia is significantly low.
- The effectiveness of the autumn 2016 vaccination campaign is critical for managing potential influenza epidemics.
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