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Fully Integrated Light-Sensing Stimulator Design for Subretinal Implants.

Hosung Kang1, Wajahat H Abbasi2, Seong-Woo Kim3

  • 1Department of Medical Science, Korea University, Seoul 02841, Korea. 2017010569@korea.ac.kr.

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Summary
This summary is machine-generated.

This study introduces a low-power, low-mismatch photodiode stimulator for subretinal prostheses. The novel design reduces power consumption and fabrication costs for improved retinal stimulation.

Keywords:
digital controllerex-vivo demonstrationhigh-density pixelsimplantable devicelight sensorphotodiodesubretinal prosthesis

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Area of Science:

  • Biomedical Engineering
  • Retinal Prosthetics
  • Integrated Circuit Design

Background:

  • Subretinal prostheses require high-density pixel arrays for vision restoration.
  • Existing designs face challenges with high power dissipation, fabrication costs, and retinal tissue damage due to residual charges.
  • Need for efficient and cost-effective stimulation solutions in retinal implant technology.

Purpose of the Study:

  • To develop a fully integrated, low-power, and low-mismatch photodiode-based stimulator for subretinal prostheses.
  • To address the limitations of current high-density pixel stimulators.
  • To reduce power consumption and fabrication costs while minimizing retinal tissue damage.

Main Methods:

  • Utilized a switched-capacitor current mirror technique for the single-pixel stimulator (SPStim).
  • Integrated a customized P+/N-well photodiode for light sensing.
  • Fabricated a 64-pixel stimulator array using a standard 0.35-μm CMOS process.

Main Results:

  • Achieved a maximum biphasic pulse amplitude of 143 μA.
  • Demonstrated low average power consumption of 167 μW during a 5 ms stimulation period.
  • Reported a low average mismatch of 1.12% between cathodic and anodic pulses.

Conclusions:

  • The developed SPStim offers a viable solution for low-power, low-mismatch stimulation in subretinal prostheses.
  • The photodiode-based design reduces fabrication costs and complexity.
  • Ex-vivo demonstration confirms the efficacy and performance of the integrated stimulator for potential vision restoration applications.