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Differential associations between depression and cognitive function in MCI and AD: a cross-sectional study
Chang Hyun Lee1,2, Do Hoon Kim1,2, Yoo Sun Moon1,3
1Department of Psychiatry, Chuncheon Sacred Heart Hospital, Hallym University College of Medicine, Chuncheon, South Korea.
International Psychogeriatrics
|January 31, 2019
Summary
Depression impacts cognitive function differently in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Cognitive decline associated with depression is more pronounced in MCI patients, particularly in memory and executive functions.
Area of Science:
- Neuroscience
- Gerontology
- Psychiatry
Background:
- Cognitive deficits in depression may vary with neurocognitive impairment levels.
- Evidence differentiating depression's cognitive impact across impairment stages is limited.
Purpose of the Study:
- To investigate the differential association between depression and cognitive function in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD).
Main Methods:
- Cross-sectional analysis of 1,724 MCI and 1,247 AD patients.
- Assessed depression using the Korean Geriatric Depression Scale.
- Measured cognition across five domains using the Seoul Neuropsychological Screening Battery.
Main Results:
- Depression showed significant differences in visuospatial, memory, and executive function in MCI, and attention in AD.
- The link between depressive symptoms and cognitive function was stronger in MCI than AD.
- These associations were most pronounced in memory and executive function for MCI patients.
Conclusions:
- The association between depression and cognitive decline is more significant in MCI compared to AD.
- Depression's impact on cognitive domains like memory and executive function is more pronounced in the earlier stages of cognitive impairment (MCI).
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