Related Experiment Video
Updated: Jan 30, 2026

High-Throughput Dissociation and Orthotopic Implantation of Breast Cancer Patient-Derived Xenografts
Published on: December 20, 2024
The breast cancer patient in the cardioncology unit
Daniela Cardinale1, Vincenzo Caruso1, Carlo M Cipolla1
1Cardioncology Unit, Cardiology Division, IEO, European Istitute of Oncology, IRCCS, Milan, Italy.
Insights
Breast cancer treatments improve survival but can cause heart problems, especially in older patients. Cardioncology helps manage cardiovascular risks, protecting patients from heart disease during and after cancer therapy.
Area of Science:
- Cardiology
- Oncology
- Cardio-oncology
Background:
- Breast cancer management advances have improved survival rates.
- Cardiovascular side effects are a significant concern, becoming the leading cause of mortality in older breast cancer survivors.
- Managing cardiovascular risk is critical to prevent treatment-induced morbidity and mortality.
Purpose of the Study:
- To highlight the importance of cardioncology in managing cardiovascular risks associated with breast cancer therapy.
- To discuss strategies for risk stratification, early diagnosis, prevention, and treatment of cardiotoxicity.
- To emphasize the interdisciplinary approach needed to minimize long-term cardiovascular disease in cancer patients.
Main Methods:
- This review discusses the advantages of a cardioncology approach.
- It covers risk stratification, monitoring for early diagnosis, prevention, and early treatment of cardiotoxicity.
- The review emphasizes evidence-based indications and interdisciplinary expertise.
Main Results:
- Cardioncology facilitates a proactive approach to cardiovascular health in breast cancer patients.
- Early identification and management of cardiotoxicity can mitigate severe side effects.
- An integrated cardiology-oncology strategy can prevent long-term heart disease and preserve therapeutic options.
Conclusions:
- Cardioncology is essential for optimizing breast cancer treatment outcomes while preserving cardiac health.
- Interdisciplinary collaboration is key to reducing cardiovascular morbidity and mortality.
- Preventing 'the heart patient of tomorrow' is a primary goal of modern cancer care.
Abstract:
The breakthroughs of breast cancer management have led to a significant improvement in patient survival. However, to obtain this outcome a considerable price has been paid regarding cardiovascular side effects. Indeed, cardiovascular disease is the main cause of mortality in patients with breast cancer over fifty years of age, contributing more than cancer mortality in older cancer survivors. Thus, the identification and the management of patients with breast cancer at risk for cardiovascular events has become critical in order to reduce morbidity and mortality from cardiovascular toxicity due to cancer therapy, which may blunt its effectiveness. Today, cardioncology is a novel and recognized medical discipline, which aims to encourage a close interaction between cardiology and oncology, explore new strategies, collect evidence-based indications, and develop interdisciplinary expertise with the ultimate goal of minimize the risk of developing cardiovascular disease during and after anticancer therapy, prevent the breast cancer patient cured today from becoming the heart patient of tomorrow, and avoiding the possibility that pre-existent cardiac disease be a barrier leading to a reduction of a patient's therapeutic opportunities. In this review we discussed the advantages of a cardioncology approach in terms of risk stratification, monitoring for early diagnosis, prevention, and early treatment of cardiotoxicity.
Related Concept Videos
Measurement: Standard Units
Measurement: Derived Units
Units of Measurement
There are various well-known historical measurement systems, such as the Babylonian system, the Roman system, the Egyptian system, the Olympian system, the British system, and the Indus...
International System of Units
Prefixes are used to define both larger and smaller quantities in the SI system. For example, milli, micro, and nano define smaller quantities, while kilo, mega, and giga are used to define...
Motor Units
Motor Units
Motor units come in different sizes, with smaller units...

