[VALUE OF METALPROTEINASES OF BLOOD IN PATHOGENESIS OF EPITELIAL SKIN TUMORS AND THE POSSIBILITY OF THEIR SURGICAL...

Research objective - to carry out studying of changes of metalproteinases of blood at patients with epitelial cancer of skin in the postoperative period. Changes of TIMP-1 and MMP-2, MMP-7 and MMP-9 of blood it has been studied at 98 patients with various cancer of skin whose age was 55±3 years. From them bazalnokletochny cancer of skin - at 39 people, planocellular cancer is skin - at 39 patients. Researches were conducted before expeditious treatment, in the first postoperative days, for the fifth, seventh, tenth postoperative days and in 18 months after the undergone operation. For comparison at 20 patients operated with skin fibroma. Studying of indicators was carried out for the same days. At all patients the diagnosis is confirmed morphologically before performing expeditious treatment. Expeditious treatment was carried out under local anesthesia, at cancer broad excision of education was carried out, at fibroma - education excision. The conducted researches of indicators of inhibitor of metalproteinases-1, matriksny metalproteinases of blood at patients with various skin tumors show that in pathogenesis of development of a tumor of epitelialny tumors the great value is given to increase in inhibitor of metalproteinases-1, matriksny metalproteinases of blood. So, it is established that prior to expeditious treatment in all groups, both malignant, and good-quality increase in all studied indicators has been registered. It should be noted that increase in these indicators depended on malignancy of a tumor. So, in group with good-quality formations of skin this increase was minimum, and in group with planocellular cancer of skin - maximum. It is possible to assume that each tumor produces in TIMP-1, MMP-2, MMP-7 and MMP-9 blood, and this quantity depends on the nature of malignancy of a tumor. Besides, in the course of the research it has been established that performance of surgical treatment at benign tumors is led to correction of this indicator that it is shown by normalization of these indicators. At the same time at bazalnokletochny cancer of skin only to partial decrease in an indicator, and at planocellular cancer of skin these indicators didn't change. From this it is possible to make the conclusion that surgical treatment doesn't lead to correction of these indicators at malignant new growths of skin.