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[INFLUENCE OF CHRONIC IMMOBILIZATION STRESS DURING PREGNANCY ON MORPHOFUNCTIONAL STATE OF THE LIVER IN FEMALE RATS
1Kharkiv National Medical University, Ukraine.
Abstract:
Morphofunctional state of the liver (in particular, indexes of carbohydrate, protein, and fat metabolism, structural elements and condition of vascular endothelium of the liver) in female rats subjected to immobilization stress during pregnancy, has been studied. Morphological changes in the liver include discomplexation of beam-radial structure, pyknosis of hepatocyte nucleus, increased regeneration activity of parenchyma, and increased stromal parenchymal index. Functional disorders are manifested by development of dysproteinemia, hyperlipidemia, hyperglycemia, and increased activity of organo-specific liver enzymes. It testifies to risk of fibrosis and diffuse nodular cirrhosis development in the animals, as well as diabetes mellitus of type II in the future.
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