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A Comprehensive Review of Patient-reported Outcomes in Patients With Chronic Liver Diseases

Zobair M Younossi1,2, Pegah Golabi1,2, Linda Henry2,3

  • 1Department of Medicine, Center for Liver Diseases, Inova Fairfax Hospital.

Journal of Clinical Gastroenterology
|February 1, 2019
PubMed

Insights

Chronic liver disease (CLD) significantly impacts patients

Area of Science:

  • Hepatology and Gastroenterology
  • Patient-Reported Outcomes Research
  • Clinical Epidemiology

Background:

  • Chronic liver disease (CLD) presents a substantial global health challenge, contributing significantly to mortality worldwide.
  • Beyond clinical manifestations, CLD profoundly affects patients' health-related quality of life and other patient-reported outcomes (PROs).
  • Integrating clinical data with PROs offers a comprehensive understanding of the disease burden on patients.

Purpose of the Study:

  • To review the assessment of patient-reported outcomes (PROs) in various chronic liver diseases.
  • To summarize the available validated tools and questionnaires for measuring PROs in CLD patients.
  • To provide a resource for investigators and clinicians interested in the patient experience of liver disease.

Main Methods:

  • Literature review of studies assessing patient-reported outcomes in chronic liver disease.
  • Identification and categorization of validated questionnaires and tools used for PRO assessment in CLD.
  • Synthesis of findings on the application of PROs in understanding the impact of CLD and its treatments.

Main Results:

  • Various generic and disease-specific instruments, such as the Short Form-36 and Chronic Liver Disease Questionnaire, are available for PRO assessment.
  • PRO instruments are crucial for evaluating the impact of CLD's natural history and treatment interventions on patients' experiences.
  • The review highlights the importance of PROs in capturing the comprehensive burden of liver disease.

Conclusions:

  • Patient-reported outcomes (PROs) are essential for a holistic assessment of chronic liver disease (CLD) impact.
  • Validated tools are available to measure PROs, aiding in understanding patient experiences.
  • This review provides a valuable summary of PRO assessment methods for researchers and clinicians in the field of hepatology.

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