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Updated: Jan 30, 2026

In Silico Clinical Trials for Cardiovascular Disease
Published on: May 27, 2022
Potential protective effects of red yeast rice in endothelial function against atherosclerotic cardiovascular disease
Shu-Jun Feng1, Zhi-Han Tang2, Ying Wang3
1Department of Cardiology, The First People's Hospital of Chenzhou, University of South China, Chenzhou 423000, China.
Abstract:
Atherosclerotic cardiovascular disease (ASCVD) is the deadliest disease in the world, with endothelial injury occurring throughout the course of the disease. Therefore, improvement in endothelial function is of essential importance in the prevention of ASCVD. Red yeast rice (RYR), a healthy traditional Chinese food, has a lipid modulation function and also plays a vital role in the improvement of endothelial reactivity and cardiovascular protection; thus, it is significant in the prevention and treatment of ASCVD. This article reviews the molecular mechanisms of RYR and its related products in the improvement of endothelial function in terms of endothelial reactivity, anti-apoptosis of endothelial progenitor cells, oxidative stress alleviation and anti-inflammation.
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