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Updated: Jan 30, 2026

Author Spotlight: A Reproductive Hysteroscopy Approach for Complete Endometrial Polyp Removal and Enhanced Endometrial Receptivity
Published on: August 2, 2024
Chronic Endometritis, a Common Disease Hidden Behind Endometrial Polyps in Premenopausal Women: First Evidence From a
Ettore Cicinelli1, Stefano Bettocchi1, Dominique de Ziegler2
1Department of Biomedical and Human Oncological Science, 2nd Unit of Obstetrics and Gynecology, University of Bari, Bari, Italy (Drs. Cicinelli, Bettocchi, Loizzi, Cormio, Marinaccio, Trojano, Crupano, and Francescato).
Study Objective:
To investigate the correlation between endometrial polyps (EPs) and chronic endometritis (CE).
Design:
Single-center retrospective case-control study.
Setting:
Academic center.
Patients:
A total of 480 premenopausal women with abnormal uterine bleeding (AUB) were enrolled. Group A included 240 women suffering from EPs (diagnosed by hysteroscopy and histology), and group B included 240 patients without EPs at hysteroscopy.
Interventions:
In group A, 2 separate samples were obtained from the EPs (group A polyps) and endometrium (group A endometrium). In group B, a single sample of endometrial tissue was evaluated (group B endometrium). All tissue samples were subjected to immunohistochemistry for CD-138 for plasma cell identification.
Measurements And Main Results:
The primary study endpoint was to compare the rates of CE in group A endometrium versus group B endometrium. The secondary endpoint was to evaluate the consistency in CD-138 immunoreactivity between group A polyps and compared with group A endometrium. A higher prevalence of CE was observed in group A endometrium compared with group B endometrium (p < .0001). The total percentage of EPs showing CD-138 positivity was 76.7% (184 of 240). CE was more frequent in women with CD-138+ EPs compared to those with CD-138- EPs (p < .0001).
Conclusions:
EPs were commonly associated with CE in the premenopausal women suffering from AUB. Moreover, the majority of EPs were positive for CD-138 staining, suggesting a possible hidden association between chronic inflammation and EPs.
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