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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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MicroRNAs and Transplantation.

Zahraa Khan1, Manikkam Suthanthiran1, Thangamani Muthukumar1

  • 1Division of Nephrology and Hypertension, Department of Medicine, New York-Presbyterian-Weill Cornell Medicine, 525 East 68th Street, Box 3, New York, NY 10065, USA; Division of Nephrology and Hypertension, Department of Transplantation Medicine, New York-Presbyterian-Weill Cornell Medicine, 525 East 68th Street, Box 3, New York, NY 10065, USA.

Clinics in Laboratory Medicine
|February 3, 2019
PubMed
Summary
This summary is machine-generated.

MicroRNAs (miRNAs) are key regulators of gene expression and show promise as biomarkers for monitoring kidney transplant health. Studies reveal altered miRNA expression in rejection and fibrosis, aiding in allograft assessment.

Keywords:
BiomarkersKidney transplantationRejectionmiRNA

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Describing a Transcription Factor Dependent Regulation of the MicroRNA Transcriptome
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Area of Science:

  • Molecular Biology
  • Genetics
  • Transplantation Immunology

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs regulating gene expression.
  • miRNAs are increasingly recognized for their potential as biomarkers in various diseases.
  • Assessing kidney allograft status is crucial for long-term transplant success.

Purpose of the Study:

  • To review miRNA biogenesis and function.
  • To provide an overview of miRNA quantification tools.
  • To summarize studies on miRNA expression in kidney allografts and recipients.

Main Methods:

  • Review of literature on miRNA biology and quantification.
  • Analysis of miRNA expression in kidney allografts with and without rejection or fibrosis.
  • Synthesis of published data on miRNA patterns in kidney transplant recipients.

Main Results:

  • miRNA expression is altered in kidney allografts experiencing acute rejection or fibrosis.
  • Specific miRNA profiles correlate with different pathological states in kidney transplants.
  • Published data indicate distinct miRNA expression patterns in kidney transplant recipients.

Conclusions:

  • miRNAs are promising biomarkers for non-invasive assessment of kidney allograft status.
  • Understanding miRNA alterations can improve diagnosis and management of kidney transplant complications.
  • Further research into miRNA profiling may enhance personalized transplant care.