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Updated: Jan 30, 2026

Investigating the Immunological Mechanisms Underlying Organ Transplant Rejection
Published on: August 20, 2007
Immunologic Effects of the Microbiota in Organ Transplantation
1Department of Molecular Biology and Biochemistry, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada; Centre for Cell Biology, Development and Disease, Simon Fraser University, 8888 University Drive, Burnaby, BC V5A 1S6, Canada.
Abstract:
The microbiota is a community of microbes that colonizes body surfaces. It has many effects that influence immune activation and regulation. The success of organ transplantation is limited by rejection of grafts by the immune system so it is important to understand how immunologic responses are controlled in this setting. This review discusses the immunologic effects of the microbiota and how this microbial community may affect organ transplant rejection.
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