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Updated: Jan 29, 2026
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MRI-guided dmPFC-rTMS as a Treatment for Treatment-resistant Major Depressive Disorder
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New Treatment Options for Depression: A Primer for Internists
Tina H Byun1, Swarna S Chaliki1, Kenneth G Poole1
1Division of Community Internal Medicine, Mayo Clinic, Scottsdale, Ariz.
The American Journal of Medicine
|February 3, 2019
Summary
Major depressive disorder treatment is complex. This review covers recent medication advancements for primary care providers managing depression, offering insights into newer therapeutic options.
Area of Science:
- Psychiatry and Primary Care Medicine
- Pharmacology and Therapeutics
Background:
- Depression remains a significant clinical challenge with diverse treatment modalities.
- Primary care physicians frequently manage major depressive disorder (MDD) beyond initial treatment lines.
Purpose of the Study:
- To review recent advancements in pharmacotherapy for depression.
- To equip general internists and other primary care providers with knowledge of novel depression treatments.
Main Methods:
- Literature review of recent developments in depression pharmacotherapy.
- Synthesis of information on newer medication classes and agents.
Main Results:
- Emerging pharmacologic options offer alternatives for treatment-resistant depression.
- Understanding newer antidepressants is crucial for optimizing patient care.
Conclusions:
- Primary care providers require updated knowledge on novel depression treatments.
- Recent pharmacologic developments expand therapeutic options for major depressive disorder.
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